Accelrys Software: CNX

CNX is based on the widely used programs X-PLOR and CNS. CNX extends the capabilities of these programs and offers functionality that can significantly increase the speed of the structure solution process. It integrates X-ray diffraction and NMR spectroscopic data with molecular mechanics, dynamics, and energy minimization to aid in the solution of three-dimensional molecular structures. In addition, CNX offers state of the art algorithms such as maximum likelihood refinement for X-ray refinement and residual dipolar coupling restraints for NMR structure determination. All of these protocols can be easily setup and customized through an HTML-based interface that provides template protocols. In addition, CNX supports the use of several force fields including the Engh-Huber and CHARMm¨ force fields. CNX is supported on IBM (AIX), SGI, and LINUX platforms. The following modules within CNX are available: CNX, CNXDL, CNX-NMR and CNX-X-ray.